Basic Info.
Model NO.
Lingding135062-02-1
Type
Pharmaceutical Intermediates
Transport Package
Based on Customer′s Needs
Product Description
Product Description Regrelinide is a kind of diabetes treatment drug, which belongs to non-sulfonylurea in-sulin releasing agent. It was successfully developed by BoehringerIngelheim, Germany, and approved by FDA in December 1997. In 1998, Regrelinide was launched in the United States and European countries successively under the brand name Novolone. Clinically, it is mainly used to treat patients with type II diabetes mellitus (non-in-sulin dependent type) who cannot effectively control hyperglycemia through diet control, weight reduction and exercise. In 2008, the FDA approved NovoNordisk's replaglinide+metforminHCl (PrandiMet) tablet for the treatment of type 2 diabetes. From the perspective of chemical structure, repaglinide is a carbamylmethylbenzoic acid derivative, which is a fast acting and short acting time of in-sulin secretion promoting prandial blood glucose regulator. The main mechanism of action is to close the potassium channel on the β cell membrane, resulting in the influx of calcium ions, and increase the concentration of calcium ions in the cell, so as to stimulate in-sulin secretion. However, the receptor sites are different from those of sulfonylurea drugs, and the drugs do not enter the beta cells, inhibit protein synthesis or directly cause exocytosis of in-sulin. Its absorption and metabolism are rapid, the drug peak and half life is about 1 hour, after taking the drug plasma in-sulin concentration rapidly and significantly increased, resulting in a significant decrease in blood sugar. Therefore, the method of taking this medicine is to eat, do not eat do not take, is the so-called "meal blood sugar regulator". Each dose was 0.25g and 2g. Flexible medication can reduce hypoglycemia caused by missed meals and delayed meals. After taking the medicine for half a year, it can reduce postprandial blood glucose by 6mmol/L, fasting blood glucose by 4mmol/L, and HbAlc2%. Significantly improved glycemic control compared with placebo. Repaglinide is as effective as metformin for blood sugar in obese patients with type 2 diabetes, and is more effective in combination with metformin than alone. Safety studies have shown no significant hypoglycemia and liver damage, few drug interactions and good tolerance.
Matters needing attention:
1. Repaglinide can induce hypoglycemia like most other oral in-sulin stimulating drugs. Combined with metformin increases the risk of hypoglycemia. If persistent hyperglycemia still occurs after combined medication, oral hypoglycemic agents can no longer be used to control blood sugar, but in-sulin therapy should be used instead. High blood sugar can occur in response to a stress response, such as fever, trauma, infection, or surgery.
2. Like other oral hypoglycemic drugs, patients must use them with caution to avoid hypoglycemia while driving.
3, excessive medication may cause hypoglycemic symptoms, such as dizziness, sweating, tremor, headache, etc. Once these reactions occur, effective measures should be taken to correct hypoglycemia, such as oral sugars. More severe hypoglycemia accompanied by seizures, loss of consciousness, or coma should be treated with intravenous glucose.
4. When used with monoamine oxidase inhibitors (MAOI), non-selective beta-blockers, angiotensin converting enzyme inhibitors (ACEI), non-steroidal anti-inflammatory drugs, salicylate, octreotide, ethanol, and anabolic hormones, the hypoglycemic effect of reloglinide is enhanced.
5. When used with oral contraceptives, thiazines, glucocorticoids, danazoles, thyroxine hormones and sympathomimetic drugs, the hypoglycemic effect of this product will be weakened.
6. CYP3A4 inhibitors (such as ketoconazole, i-traconazole, fluconazole), erythromycin, and Mibifadil may increase plasma levels of this product.
7. Cyp3a4-inducing drugs, such as rifamp-icin or phenytoin, may reduce plasma levels of this product. Product Name: | Repaglinide |
CAS: | 135062-02-1 |
MF: | C27H36N2O4 |
MW: | 452.59 |
Melting point: | 130ºC |
Mol File: | 135062-02-1.mol |
Packaging & Shipping
Shipping Terms |
By Express | By Air | By Sea |
Suitable for under 50kg Fast: 3-7 days Door to door service, easy to pick up the goods | Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed | Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed |
Company Profile
Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market. Welcome domestic and foreign customers to negotiate.
Address:
Room1810, Future Time Zhongshan Road, Shijiazhuang, Hebei, China
Business Type:
Manufacturer/Factory
Business Range:
Agriculture & Food, Health & Medicine
Company Introduction:
Hebei Lingding Biotechnology Co., Ltd. is a professional business company, that include pharmaceutical raw materials, pharmaceutical intermediates, and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer′s serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company′s products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries. The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market. Welcome domestic and foreign customers to negotiate.