|Molecular Formula||C12H13N5O4|Hot sell
Gs-441524 is phosphorylated into nucleoside monophosphate (NMP) by cytokinase in cells, and then transformed into an active triphosphate metabolite (NTP structural analogue). In viral RNA synthesis, the active NTP analogues compete with the naturalnucleosides (ATP, TTP, CTP, GTP) to participate in RNA transcription. When gs-441524 is inserted into the transcription products, the transcription will be terminated in advance, thus inhibiting the viral RNA transcription process.When gs-441524 is inserted into the transcription products, the transcription will be terminated in advance, thus inhibiting the viral RNA transcription process.
If a cat's immune system is healthy and mature, the white blood cells should fight off an infection or virus, and allow the cat to build up an immune response, or antibodies. Cats who develop FIP have an immune defect or deficiency that causes the white blood cells to replicate, rather than fight, the virus. Essentially, the cats immune system is spreading the virus throughout the cat's body rather than trying to eliminate it. Cats who have no immune response develop wet FIP, while cats who have a partial immune response develop dry FIP. The nucleoside analog GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate molecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polymerase. In layman's terms, GS441 interjects itself into the chain reaction and stops the replication of the virus.
Dr Pedersen's case study determined that a successful course of treatment with GS441 is 12 weeks, administered daily. Some owners have stopped treating once blood work and diagnostics returned to normal; however, the few cats who did relapse were among those who stopped prior to the 12 week protocol. Because the course of treatment is both emotionally and financially taxing, most owners currently using GS opt to pursue the full 12 weeks, to ensure the highest probability of success. Cats who undergo the full 12 weeks and remain symptom-free for 90 days following conclusion of treatment are officially cured of FIP.
GS441 comes in both injectable form, and as of June 2019, a pill form. Both are administered daily and the dose is based on the weight of the cat. For wet & dry FIP without neurological or ocular symptoms, the recommended dosage is 5mg (GS) x weight (kg) / GS concentration per 1mL = dose per 24 hr. Neurological and Ocular FIP cats require 7mg/kg MINIMUM, and can go as high as 10mg/kg for extreme ocular or neurological cases.A dosing calculator can be found here.It is important to note that the dosage should not be reduced during the course of treatment, regardless of how well the cat is responding. Conversely, if the cat is not responding to the starting dosage, it is safe to increase. It is also crucial to check the cat's weight often, and adjust the daily dose accordingly. The only known side effect of GS441 is skin lesions or burns, due to the acidity of the solution (injectable form). For this reason, it is recommended to always clean the cat's skin after giving an injection. Many owners also opt to give oral CBD oil or Hemp oil 30-60 minutes before injecting, to help minimize the stress. Should you opt to do this, it is critical that the product be veterinary grade and the proper dose should be determined by a veterinarian. CBD and/or hemp oil can be fatal to a cat if not administered properly. More commonly, Gabapentin, a mild pain medication can be given orally 60-90 minutes prior to the injection. The vast majority of cats using GS tolerate the injections just fine without the need for any pain medication or sedative.
Packaging & Shipping
|Quantity(Metric Tons)||1 - 1||2 - 20||>20|
|Est. Time(days)||10||25||To be negotiated|
Hebei Lingding Biotechnology Co., Ltd. is a professional business company ,that include pharmaceutical raw materials, pharmaceutical intermediates,and other more than 1000 products of the enterprise, The registered capital is 3 million yuan, it is a collection of scientific research, production and sales in one of the enterprises.
Since its establishment, the company has always adhered to the core concept of "focus on products, attentive service", adhere to the business purpose of "innovation, professional, win-win", to provide customers with a full range of meticulous and thoughtful services. We will adhere to the customer's serious and responsible attitude, comply with the standardized operation procedures, with efficient execution to complete customer needs.
The company's products are sold all over the world, mainly exported to the United States, Europe, Southeast Asia, Australia, the Middle East and South Africa and other countries.The company has a strong scientific research and technical team, can provide customers with high quality products and a full range of services. We will provide first-class products and better service to face the needs of customers, to meet the challenges of the market. Welcome domestic and foreign customers to negotiate.
1.Any inquiry or message will be replied within 12 hours.
2.Professional manufacturer. Welcome to visit our website.
3.API, Intermediate are available, we can offer Custom Synthesis, and registration as well.
Q1. Are you a manufacturer?
Answer: Yes, we have our own factory.
Q2. Do you have GMP or DMF?
Answer: Yes, we have GMP certificate for some products, and we can provide DMF as well.
Q3. What information should I let you know if I want to get a quotation?
Answer: -Quality you require, eg. Assay, Purity, or single impurity
-Quantity you need
-Standard you want, such as USP, EP, JP etc.
Q4. How to make the payment?
Answer: T/T in advance are highly recommended. We can accept Western Union,
Money Gram and Paypal as well.
Q5. When will you deliver the goods?
Answer: For sample(less than 1kg), in about 3 working days after payment; for larger orders (more than 1kg), in about 7 working days after payment.
Q6. How will you deliver the goods?
Answer: We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS, China Air Post. For container products, we can do sea shipping. You also can choose your own shipping forwarder.
Q7. When will we receive the goods?
Answer: For samples, we will send by TNT/DHL/FEDEX/UPS express, usually it takes about 3-5 to reach you; for larger orders, it will take about 7 -10days at most.
Q8. What if we find your products unsatisfied?
Answer: We will send you a COA (Certificate of Analysis) to you first for you to confirm the quality, but if you find our products not confirm with the COA after you receive it, please show us your test result, we will refund you once we confirm that.
Q9.Do you have stock?
Answer:As we know,most customers prefer stock,so we will try to keep stock for some products.